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关键词： Co-occurrence analysis   co-citation analysis   keywords analysis   trends   CiteSpace   CELL-CYCLE ARREST   OXIDATIVE STRESS   APOPTOSIS   CANCER   CISPLATIN   PROLIFERATION   INHIBITION   EXPRESSION   EXTRACT  

摘要： ContextTraditional Chinese Medicine (TCM) is effective as a cancer treatment modality. However, this is the first bibliometric analysis of TCM in lymphoma treatment.ObjectiveThis study explores the current trends and research topics of TCM in treating lymphoma from 2000 to 2023.Materials and methodsWe searched within the Web of Science Core Collection (WoSCC) for publications on TCM in lymphoma treatment, spanning 2000 to 2023. Subsequently, we employed a comprehensive approach utilizing CiteSpace software and VOSviewer to visually analyze research trends, authors, institutions, co-cited references, and keywords.ResultsFrom January 1, 2000, to August 31, 2023, annual scientific publications on TCM for lymphoma treatment have steadily increased. Among the leading institutions in this field, the Beijing University of Chinese Medicine and the Fujian Medical University occupied the top positions. Regarding the authors, Jun Peng, Jiumao Lin, and Hongwei Chen emerged as the top three contributors. In the co-citation analysis of references, the top three co-cited references were authored by Hanahan D, Elmore S, and Livak KJ with citations numbered 13, 14, and 17, respectively. In particular, keywords reflecting current emerging trends included 'pathway', 'traditional Chinese medicine', 'oxidative stress', and 'macrophage polarization'.Discussion and conclusionsThis bibliometric analysis provides a comprehensive overview of TCM for lymphoma treatment. This analysis identified the predominant trends and research topics in the field. The findings are expected to be of significant value for researchers who focus on TCM in lymphoma treatment, helping them better understand the development of this field.

关键词： Microcirculation   kidney   CiteSpace   bibliometrics   web of science database   ACUTE KIDNEY INJURY   PROGRESSION   OUTCOMES   DISEASE   RATS  

摘要： BackgroundRenal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal. However, a thorough bibliometric analysis in this area remains lacking. Therefore, we aim to provide valuable insights through a bibliometric analysis of renal microcirculation literature using the Web of Science database.MethodsWe collected renal microcirculation-related publications from the Web of Science database from January 01, 1990, to December 31, 2022. The co-authorship of authors, organizations, and countries/regions was analyzed with VOSviewer1.6.18. The co-occurrence of keywords and co-cited references were analyzed using CiteSpace6.1.R6 software to generate visualization maps. Additionally, burst detection was applied to keywords and cited references to forecast research hotspots and future trends.ResultsOur search yielded 7462 publications, with the American Journal of Physiology-Renal Physiology contributing the most articles. The United States, Mayo Clinic, and Lerman Lilach O emerged with the highest publication count, indicating their active collaborations. 'Type 2 diabetes' was the most significant keyword cluster, and 'diabetic kidney disease' was the largest cluster of cited references. 'Cardiovascular outcome' and 'diabetic kidney diseases' were identified as keywords in their burst period over the past three years.ConclusionOur bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. While the trends discerned from the literature emerging opportunities in diagnostic innovation, renal microcirculation research, and precision medicine interventions, their translation to clinical practice is anticipated to be a deliberate process.

关键词： Bibliometrics   EMT   immunotherapy   VOSviewer   CiteSpace   therapeutic strategies   IMMUNE CHECKPOINTS   CANCER METASTASIS   EMT   IMMUNOSUPPRESSION   CELLS   MICROENVIRONMENT   BLOCKADE   INSIGHTS   TRENDS  

摘要： Immunotherapy has recently attracted considerable attention. However, currently, a thorough analysis of the trends associated with the epithelial-mesenchymal transition (EMT) and immunotherapy is lacking. In this study, we used bibliometric tools to provide a comprehensive overview of the progress in EMT-immunotherapy research. A total of 1,302 articles related to EMT and immunotherapy were retrieved from the Web of Science Core Collection (WOSCC). The analysis indicated that in terms of the volume of research, China was the most productive country (49.07%, 639), followed by the United States (16.89%, 220) and Italy (3.6%, 47). The United States was the most influential country according to the frequency of citations and citation burstiness. The results also suggested that Frontiers in Immunotherapy can be considered as the most influential journal with respect to the number of articles and impact factors. "Immune infiltration," "bioinformatics analysis," "traditional Chinese medicine," "gene signature," and "ferroptosis" were found to be emerging keywords in EMT-immunotherapy research. These findings point to potential new directions that can deepen our understanding of the mechanisms underlying the combined effects of immunotherapy and EMT and help develop strategies for improving immunotherapy.

关键词： Colorectal cancer   immunotherapy   bibliometric study   research trends   VOSviewer   CiteSpace   MICROSATELLITE INSTABILITY   IMMUNE MICROENVIRONMENT   SOLID TUMORS   NIVOLUMAB   IPILIMUMAB   DEFICIENT   THERAPY   TRENDS   SAFETY  

摘要： Immunotherapy, particularly immune checkpoint inhibitor (ICIs) therapy, stands as an innovative therapeutic approach currently garnering substantial attention in cancer treatment. It has become a focal point of numerous studies, showcasing significant potential in treating malignancies, including lung cancer and melanoma. The objective of this research is to analyze publications regarding immunotherapy for colorectal cancer (CRC), investigating their attributes and identifying the current areas of interest and cutting-edge advancements. We took into account the publications from 2002 to 2022 included in the Web of Science Core Collection. Bibliometric analysis and visualization were conducted using CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel. The quantity of publications associated with this domain has been steadily rising over the years, encompassing 3753 articles and 1498 reviews originating from 573 countries and regions, involving 19,166 institutions, 1011 journals, and 32,301 authors. In this field, China, the United States, and Italy are the main countries that come forward for publishing. The journal with the greatest impact factor is CA-A Cancer Journal for Clinicians. Romain Cohen leads in the number of publications, while Le Dt stands out as the most influential author. The immune microenvironment and immune infiltration are emerging as key hotspots and future research directions in this domain. This research carries out an extensive bibliometric examination of immunotherapy for colorectal cancer, aiding researchers in understanding current focal points, investigating possible avenues for research, and recognizing forthcoming development trends.

关键词： 绝经后骨质疏松   高被引论文   科学网   WoS   文献计量学   Citespace   可视化   知识图谱   序贯治疗   骨质疏松性椎体骨折  

摘要： 背景:基于主题文献的计量学和可视化分析对了解绝经后骨质疏松症研究基础与前沿尤为重要。目的:对近20年绝经后骨质疏松研究的高被引SCI论文进行文献计量、引证和可视化分析。方法:对Web of Science(WoS)中SCI-EXPANDED收录的2003-2022年发表的前100篇高被引绝经后骨质疏松研究论文进行文献计量,用CiteSpace软件进行可视化分析。结果与结论:前100篇高被引论文在WoS核心合集中总被引量为67377次,每篇论文的年平均引用量为49.17次。绝经后骨质疏松研究主要涉及医学、工程技术、生物学和多学科等领域,小类学科则以内分泌学与代谢、医学:内科为主。国际上形成了稳定密切的核心合作网络关系,美国、加利福尼亚大学系统、Cummings,Steven R分别是高被引论文发文最多的国家、科研机构和作者。绝经后骨质疏松研究前沿主要涉及了钙剂、维生素D的补充治疗与骨折风险,双膦酸盐类药物治疗绝经后骨质疏松的临床研究,非典型股骨骨折,绝经后骨质疏松的新药临床研究与序贯治疗,骨折风险的预测指标,骨质疏松性椎体压缩骨折的中长期随访,基因多态性和遗传因素,绝经后骨质疏松临床实践指南的制定和更新等方面。大型的队列研究、高质量随机对照试验、系统综述和荟萃分析、临床实践指南是推动绝经后骨质疏松临床研究发展的巨大引擎。中国应在上述研究领域加大投入,以提高国际影响力。

关键词： 脊髓损伤   步行   外骨骼机器人   功能康复   研究热点   前沿   CiteSpace   可视化分析  

摘要： 背景:脊髓损伤危害严重,损伤后步行功能障碍最影响患者的日常生活能力,在该领域运用外骨骼机器人开展辅助步行康复研究日趋活跃。目的:应用CiteSpace可视化软件绘制脊髓损伤后外骨骼机器人辅助步行为主题的科学知识图谱,并探讨近10年该领域研究现状、热点及未来趋势,为该领域后续科学研究和临床运用提供借鉴。方法:利用Web of Science核心集数据库通过布尔逻辑运算符进行主题词检索,选择语种英语,检索策略:TS=“spinal cord injury OR SCI”AND“walk OR walking”AND“robot OR exoskeleton OR(exoskeleton-assisted walking)OR EAW”,利用知识图谱软件CiteSpace 6.2.R4对去重后获得的高质量文献进行发文量、国家/研究机构合作、高影响力作者/文献共被引、关键词共现/聚类/突现等主题热点、国际前沿趋势可视化分析,并绘制科学知识图谱。结果与结论:①共纳入544篇高质量文献,近10年该领域发文量、总被引频次呈增长趋势;②发文量排名前3的国家依次是美国、中国、意大利,发文量排名前3研究机构是美国退伍军人事务部、美国退伍军人健康管理局、瑞士联邦理工学院;③被引文献频次最高(167次)和中介中心性最高(0.13)的作者均为美国宾夕法尼亚Esquenazi A团队,在该领域具有较高影响力;④对被引频次、中介中心性前5共被引文献分析显示:目前针对脊髓损伤患者配备动力外骨骼设备步行康复研究重点包括在机构、家庭等真实环境中步行康复训练安全性判断、优势分析、个体化培训计划设计,动力外骨骼设备应用于胸椎及以下节段运动功能完全丧失脊髓损伤患者辅助步行效果优劣、影响因素及应用潜力等;⑤近年该领域研究热点集中于个体化(individuals)、步态(gait)、动力外骨骼(powered exoskeleton)、减重支持(body weight support)、功能性电刺激(functional electrical stimulation)、康复(rehabilitation)、辅助技术(assistive technology)、步行活动(ambulation)、恢复(recovery)等内容;⑥该领域研究早期多应用于脑卒中患者,前沿包括减重支持、往复式步态矫形器及功能性电刺激等技术手段,脊髓损伤外骨骼机器人辅助步行康复研究近年呈现上升趋势,关注点逐渐向以适应性控制为机制的医用下肢外骨骼设备研制、安全性提升、应用潜力挖掘等前沿方向转变,研究检测手段注重联合功能性近红外光谱成像等高端技术,而关注患者生活质量、提升运动训练能力及改善机体结构为该领域未来的研究热点。

关键词： 脊柱侧弯矫形器   知识图谱   文献计量学   可视化分析   Citespace  

摘要： 背景:脊柱侧弯主要指脊柱冠状位、矢状位和轴位上的序列异常,且Cobb角≥10°。脊柱侧弯患者会出现双肩不等高、背部不对称等症状,严重者可能会影响患者心肺功能,从而影响患者的日常生活。保守治疗可以控制其侧凸进展,避免后期手术。脊柱侧弯矫形器是目前保守治疗中较为有效的治疗措施。目的:对脊柱侧弯矫形器的国内外研究现状、热点及趋势进行总结分析,为相关研究提供参考。方法:以文献计量学与可视化分析为手段,用中外文献对比的方法,对近10年脊柱侧弯矫形器期刊文献进行分析。通过文献计量学得出脊柱侧弯矫形器研究的现状,使用Citespace软件对关键词进行重点分析,得出目前脊柱侧弯矫形器研究的热点及未来趋势。结果与结论:①目前脊柱侧弯矫形器文献数量仍处于波动上升趋势。中国和美国是主要研究国家,两者文献占比超过40%,但中国学者的外文文献平均引用率较低。②国内研究的基础领域主要为外科学与儿科学,而在国外主要研究领域是矫形学与临床神经学。国内中医学也有一定数量的文献,说明国内也从事中西医结合的方法治疗脊柱侧弯。国家自然科学基金在中外文献中的占比都是最高的,体现出该基金对脊柱侧弯矫形器研究的重视。③中外文献发文量最高的作者为邱勇和Negrini Stefano,发文最多的机构是南京大学医学院附属鼓楼医院脊柱外科和UDICE-French Research University。国内外作者及机构有一定交流,但不密切,需要相关机构和学者进行进一步探讨研究。④从研究热点及未来趋势来看,主要治疗类型为青少年特发性脊柱侧弯,脊柱侧弯矫形器制作方式为3D打印,主要治疗指标为侧凸进展,治疗最终目的为提升患者的生活质量。

关键词： 脊柱畸形   人工智能   卷积神经网络   全基因组分析   Citespace   VOSviewer   可视化   文献计量学  

摘要： 背景:随着人工智能技术在治疗脊柱畸形领域的不断完善与进步,已有大量的研究投入到该领域当中,但主要研究现状、热点和发展趋势尚不明确。目的:采用文献计量学的方法可视化分析人工智能在脊柱畸形领域的相关文献,明确该领域的研究热点和不足,为今后研究工作研究提供参考。方法:在Web of Science核心集数据库检索建库至2023年收录的人工智能在脊柱畸形领域相关文献,通过Citespace 5.6.R5和VOSviewer 1.6.19软件对文献数据进行可视化分析。结果与结论:(1)共纳入文献165篇,此领域年发文量呈波动上升趋势,发文量最多的作者是Lafage V,发文量最多的国家是中国。(2)关键词分析结果显示,青少年早发性脊柱侧弯、深度学习、分类、精度和机器人是该研究领域的主要高频关键词。(3)文献共被引和高被引文献深度分析结果显示,人工智能在脊柱畸形领域有3大热点,包括利用U型架构(深度学习卷积神经网络的一种成熟模式)来自动测量影像学参数(Cobb角、棘旁肌准确分割等)、多视图相关网络架构(即脊柱曲度评估框架)及机器人引导脊柱手术。(4)在人工智能治疗脊柱畸形领域,基因组学等机制研究十分薄弱,未来可利用无监督分层聚类等机器学习技术,运用全基因组关联分析等基因组学研究方法,来进行脊柱畸形领域的易感基因等基础机制研究。

关键词： Citespace   Bibliometric analysis   Biochar   Supercapacitor   Battery   Capacitive deionization  

摘要： Biochar has garnered significant attention across various fields due to its outstanding catalytic properties, making it a focal point in biochar development. This study employs Citespace software to perform a bibliometric analysis, elucidating the research hotspots and developmental trends of biochar in electrochemical energy storage devices. It visualizes the trends and research status of biochar within this context. A visual analysis network, encompassing national collaboration, institutional cooperation, and author levels, is established and categorized. Additionally, the visualization of cited documents and journal co-citation networks reveals the primary subject distribution and core journals in this domain. The main research content is identified through journal co-citation visualization. Keyword co-occurrence and burst analyses highlight current research hotspots and emerging frontiers. This comprehensive analysis explores the collaborative efforts and contributions of biochar in electrochemical energy storage devices, from individual researchers to institutions and countries, providing insights into its developmental status. The paper offers a detailed exposition, further organizing the development narrative of this field and clarifying its research hotspots and trends. The conclusions and outlooks presented can offer scholars a deeper understanding of biochar's role in electrochemical energy storage devices and guide future research directions in this area.

关键词： 农村合作经济   发展趋势   乡村振兴   CiteSpace  

摘要： 农村合作经济作为农村社会经济关系和经济活动的集合体,能够畅通城乡要素流动,促进城乡融合发展,扎实推进乡村产业、人才、文化、生态、组织振兴。本文通过中国知网文献数据,基于文献计量法,运用CiteSpace软件,以“农村合作经济”为主题词分析该领域研究热点及发展趋势。研究表明:农村合作经济领域发文量呈现下降趋势,作者和机构均缺乏有效的合作,研究视角局限于理论层面,缺乏对实践层面的研究及总结归纳。因此,未来需要学者和机构加强合作交流,挖掘新时代农村合作经济领域研究深度和实践需求,利用理论成果指导实践发展。